The application of statistical techniques to the study of manuscript books, based on the analysis of large data sets acquired through the archaeological observation of manuscripts, is one of the most original trends in codicological research, aiming not only to reconstruct on a sound basis the methods and processes used in book manufacture and their tendential evolution in space and time, but also to interpret them as the result of a dynamic interplay between various and often incompatible needs (of cultural, technical, social and economic nature) that book artisans had to reconcile in the best possible way. The present collection of essays in English translation was guided by the desire to offer a multifarious well-articulated picture of the application of statistical methodology to the various aspects of manuscript production, namely analysis of materials, characterization of book types, manufacturing techniques, planning and use of layout characterization of scripts and scribal habits. The volume aims to present to a wider readership a series of significant papers which have appeared over the last fifteen years, by means of which the statistical approach continues to demonstrate its vast potential.